Compounds of natural origin could lead to new, innovative therapeutic agents for cancer. It has been shown that Luteolin prevents tumor development largely by inactivating several signals and transcription pathways essential for cancer cells. Luteolin can keep several human cancers from growing, with Luteolin’s anti-proliferative activity being attributed to its ability to inhibit Insulin Growth Factor (IGF-1) activation, with several reports showing that flavonoids naturally inhibit cancer invasion and metastasis.
“Flavonoids are prospective compounds for anti-cancer therapy”
Luteolin is a potent anticancer agent that could halt a wide spectrum of tumors and cancer cells, including multi-drug resistant (MDR) cells. Pre-clinical and clinical trials using Luteolin as an adjuvant supplement for cancer therapy should place this fascinating agent at the forefront of new therapeutic approaches and then translate into clinical applications.
MDR is an obstacle in cancer treatment, often because less drug accumulates in tumor cells but as seen in ‘oxaliplatin-resistant cell lines’, Luteolin inhibited the Nrf2 pathway and reversed MDR.
‘Luteolin has shown exceptional ability to forage free radicals as well as demonstrate cyto-protective attributes’
According to the US Department of Agriculture, which correlates multiple small research studies and lists the food groups in an easy to read format, highlighting foods with the most abundant bio-available Luteolin. In these findings the flavonoid Luteolin was found in the highest concentrations in dried mexican oregano (not fresh). Celery seeds, juniper berries, fresh thyme, radicchio and chinese celery also had good sources of Luteolin compared to other foods.
The universal presence of flavonoids in dietary plants and their anticancer properties has prompted researchers to determine whether other flavonoids can antagonize the important Nrf2/ARE signaling pathway in the same way Luteolin seems to naturally demonstrate.
This information however, is of little or no use unless it is put squarely in the public arena, so that people on the cancer journey can make informed decisions around what natural and complementary options they have to consider as part of ‘their‘ individual therapeutic cancer healing regime.