ACQUIRED DRUG RESISTANCE – ‘COMBINATION THERAPY’ PROVING SUCCESSFUL!!

“Drug resistance is the major reason for failure in cancer chemotherapy!!”

Every Onocologist is very aware, cancerous tumors can and do become resistant to the chemotherapeutic drugs which are meant to destroy them, leaving cancer cells very difficult to target with conventional drugs alone.  Research has shown that acquired drug resistance is a common problem, where a tumor may respond initially to therapy but recur later with acquired drug resistance.  On the other hand, certain cancers may exhibit an intrinsic resistance from the outset to these cancer modulating drugs, leaving this type of treatment option less than viable.

Drug resistance is a well-known phenomenon that results when diseases become tolerant to pharmaceutical treatments.  Many anticancer drugs require metabolic activation, and thus cancer cells can develop resistance through decreased drug activation. The current paradigm states that ‘combination therapy’ should be the best treatment option because it should prevent the development of drug resistance and be more effective than any one drug on its own.

“In most cases, multiple drugs are used, as resistance to single agents occurs almost universally!!”

Chemotherapeutic drugs continue to be touted as the most effective treatment for metastatic tumors.  However, the ability of cancer cells to become simultaneously resistant to different drugs — a trait known as multi-drug resistance — remains a significant impediment to successful chemotherapy.  Three decades of multi-drug-resistance research has identified a myriad of ways in which cancer cells can elude chemotherapy, and it has become apparent that resistance exists against every effective drug, even our newest agents. Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy, with science still trying to decipher and reverse this very clever ‘cancer adaption trait’.

“Management of drug resistance is important towards successful chemotherapy”

https://www.ncbi.nlm.nih.gov/pubmed/18677966

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305362/

https://www.ncbi.nlm.nih.gov/pubmed/1913513/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190567/

http://www.nature.com/nrc/journal/v2/n1/full/nrc706.html

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