‘Protein 53’ can also be referred to as a ‘tumor suppressor gene’ and is just simply known as ‘P53’. This protein is an extremely well researched ‘Anti-Oncogene’ with one of it’s main functions being identified as ‘Guarding the Genome’. It has been shown that as many as 50% of all human tumors contain P53 mutants leading us to believe that should they have not mutated, then they would have been doing their job of regulating cell growth and division and repairing DNA. Mutant ‘P53’ can no longer bind DNA in an effective way and as a consequence ‘P21’ is not made available to act as the ‘stop signal’ for cell division. ‘P21’ is a protein involved in cell cycle regulation.
The ‘P53’ protein is known as the ‘conductor of a well orchestrated system of cellular damage detection and control’. When damage is sensed the activity of ‘P53’ protein aids in the decision between repair and the induction of cell death.
Research tells us that ‘P53’ is activated firstly by ‘Progesterone’ and secondly ‘P53’ needs to bind to ‘Zinc’, to enhance the effect of this protein. It has been shown that Progesterone (P4) induces apoptosis or ‘programmed cell death‘ and up-regulation of ‘P53’ in human ovarian carcinoma cell lines.
It has also been shown that natural compounds can assist normalization of ‘P53’, including sulphoraphane vegetables like cabbage, broccoli, cauliflower, orange fruits and vegetables, ginger, curcumin, resveratrol found in red grapes, anthocyanins found in red berries and red foods like beetroot, as well as glutathione rich foods.
Posted: 15/10/16 – Author: D. Blanch